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Monomethyl auristatin F : ウィキペディア英語版
Monomethyl auristatin F

Monomethyl auristatin F (MMAF) is a synthetic antineoplastic agent. It is part of some experimental anti-cancer antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A. In International Nonproprietary Names for MMAF-antibody-conjugates, the name mafodotin refers to MMAF plus its attachment structure to the antibody.〔(Statement on a nonproprietary name adopted by the USAN Council: Mafodotin )〕
==Mechanism of action==
Monomethyl auristatin F is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. It is linked to an antibody with high affinity to structures on cancer cells, causing MMAF to accumulate in such cells.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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